Sticking with media that are within your comfort zone is not a bad thing, but then again being prepared to spread your wings a little and try out different stuff can lead to eureka moments. We tend to think of acrylic paints as being water based and not inclined to adhere well. That may be true of some aqueous acrylic brands but it's not necessarily true of all acrylic paints. Tamiya paints, for instance, are miscible with water but are spirit based and are pretty robust, even sprayed over bare plastic. I was a diehard enamel person until a friend who rates amongst the modelling 'experten' suggested it was about time I was using acrylics. I gave Tamiya a go and it was a revelation. More recently another modelling 'experten' suggested giving GS Mr Color a go would be a Good Thing. I tried it, another revelation. These are lacquer based acrylic paints that work like enamels, only better. GS Mr Hobby is aqueous enamel and also works very well, better than other aqueous acrylic that I've used. I have to admit that with all the new paint products that are springing up it can be a bit bewildering, but I'm much more open minded these days. I still have a heap of enamels amongst my paints and I haven't given up on them completely, but I'm much more likely to try new stuff these days.
Like Ratch, I've never had any issue with cleanup, yes acrylics can set faster, but a lot of the branded thinners contain a retarder these days. For aqueous acrylic, a flush through with water at the end of a session, followed by a back flush (block the nozzle and let the air bubble out through the paint cup), then a final flush through with 90% isopropyl should be good for the next session. I habitually strip down and deep clean everything, once you get into a routine it doesn't take long.
Just to show that I'm not completely 'agin' aqueous acrylic, here's a silver Meteor painted with Citadel Mithril Silver over white primer. The older Citadel paints were superb, not sure if the new stuff works quite as well.