Hi Jimbo 100
Firstly welcome to the forum and all the best for the new year.
If you're using enamels white spirit or turps then wash hands with soapy water or washing-up liquid before the solvent have dried, a scouring pad also helps if the paint has dried. If you're using acrylics washing-up liquid usually does the trick if really stubbon add some meths, and again a scouring pad might be useful.
Hope this helps and good luck, looking forwards to seeing you modelling results.
Remember we do this for fun John the Pom